With ten points separating the two sides, anything but a win for the Reds will end their hopes of success this season - Jurgen Klopp will not feel confident after a difficult set of recent results, which makes Chelsea to win at 3.00* a valuable betting opportunity.
Liverpool (2.56*) are undefeated in each of their last four matches against Chelsea, including a 2-1 win at Stamford Bridge this season, but a repeat of this match is highly unlikely.
Goals from Dejan Lovren and Jordan Henderson settled one of the final matches in which Conte used a back four - since his formation switch, only Tottenham Hotspur have managed to take any points from Chelsea.
Liverpool have not won any of their last three Premier League games, conceding six goals in the process.
What’s more, Liverpool have not won any of their last three Premier League games and have conceded six goals in the process. All of their momentum – and new-found confidence in their defence – has evaporated with that damaging 3-2 defeat at home to Swansea City last weekend.
Consequently, Diego Costa - whose goal against Hull City proved that he is fully focused on winning the league - will expect to easily ruffle the feathers of Liverpool’s fragile back four.
Sadio Mane’s absence from the first team has clearly affected Liverpool. They have not won since his departure to Gabon for the Africa Cup of Nations, largely because Mane’s directness and dribbling speed are an important disruptive influence amongst the high-energy passing triangles of Adam Lallana and Philippe Coutinho. Without Mane, Liverpool's attacking patterns have become more predictable and easier to track.
Liverpool may have scored at least two goals in six of their previous seven matches at Anfield, but this is unlikely to continue against a defence that has kept clean sheets in six of the last eight league games.
* Odds subject to change